Publications

Microglial Responses to Alzheimer's Disease Pathology: Insights From "Omics" Studies. Reid AN, Jayadev S, Prater KE. Glia. 2025 Jan 6. doi: 10.1002/glia.24666.

Clinicopathologic Characterization of 2 Individuals With TBK1 Variants-1 Novel Splice Variant, 2 Proteinopathies: A Case Series. Domoto-Reilly K, Distad BJ, Miller DE, Lin YH, Ivanick D, Warren AS, Jayadev S, Latimer CS. Neurol Genet. 2024 Jul 24;10(4):e200173. doi: 10.1212/NXG.0000000000200173. eCollection 2024 Aug.PMID: 39055961

Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study. Suchy-Dicey AM, Domoto-Reilly K, Nelson L, Jayadev S, Buchwald DS, Grabowski TJ, Rhoads K. Alzheimers Dement. 2024 Jun;20(6):4174-4184. doi: 10.1002/alz.13849. Epub 2024 May 15.PMID: 38747387

Multiomics Blood-Based Biomarkers Predict Alzheimer's Predementia with High Specificity in a Multicentric Cohort Study. Souchet B, Michaïl A, Heuillet M, Dupuy-Gayral A, Haudebourg E, Pech C, Berthemy AA, Autelitano F, Billoir B, Domoto-Reilly K, Fowler C, Grabowski T, Jayadev S, Masters CL, Braudeau J.J Prev Alzheimers Dis. 2024;11(3):567-581. doi: 10.14283/jpad.2024.34.

Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer's disease-related neuropathology. Del Pozo A, Knox KM, Lehmann LM, Davidson S, Rho SL, Jayadev S, Barker-Haliski M.Prog Neurobiol. 2024 Apr;235:102591. doi: 10.1016/j.pneurobio.2024.102591. Epub 2024 Mar 13.PMID: 38484965

Differential effects of SORL1 deficiency on the endo-lysosomal network in human neurons and microglia. Mishra S, Jayadev S, Young JE. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220389. doi: 10.1098/rstb.2022.0389. Epub 2024 Feb 19.PMID: 38368935

A familial missense variant in the Alzheimer's disease gene SORL1 impairs its maturation and endosomal sorting.
Fazeli E, Child DD, Bucks SA, Stovarsky M, Edwards G, Rose SE, Yu CE, Latimer C, Kitago Y, Bird T, Jayadev S, Andersen OM, Young JE. Acta Neuropathol. 2024 Jan 20;147(1):20. doi: 10.1007/s00401-023-02670 1.PMID: 38244079

Microglia and complement mediate early corticostriatal synapse loss and cognitive
dysfunction in Huntington's disease. Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A, Gu X, Kim YA, Faull RLM, Jayadev S, Yednock T, Yang XW, Stevens B. Nat Med. 2023 Nov;29(11):2866-2884. doi: 10.1038/s41591-023-02566-3. Epub 2023 Oct 9.PMID: 37814059

Human microglia show unique transcriptional changes in Alzheimer's disease. Prater KE, Green KJ, Mamde S, Sun W, Cochoit A, Smith CL, Chiou KL, Heath L, Rose SE, Wiley J, Keene CD, Kwon RY, Snyder-Mackler N, Blue EE, Logsdon B, Young JE, Shojaie A, Garden GA, Jayadev S. Nat Aging. 2023 Jul;3(7):894-907. doi: 10.1038/s43587-023-00424-y. Epub 2023 May 29.PMID: 37248328

Chronic seizures induce sex-specific cognitive deficits with loss of presenilin 2 function. Knox KM, Beckman M, Smith CL, Jayadev S, Barker-Haliski M. Exp Neurol. 2023 Mar;361:114321. doi: 10.1016/j.expneurol.2023.114321. Epub 2023 Jan 9.PMID: 36634751

Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease. Course MM, Gudsnuk K, Keene CD, Bird TD, Jayadev S, Valdmanis PN. Brain. 2023 Feb 13;146(2):507-518. doi: 10.1093/brain/awac294.PMID: 35949106

Alzheimer's Disease Diagnostics Must Be Globally Accessible. Clute-Reinig N, Jayadev S, Rhoads K, Le Ny AL.J Alzheimers Dis. 2021;84(4):1453- 1455. doi: 10.3233/JAD-210663.PMID: 34690142 Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes. Prater KE, Latimer CS, Jayadev S.Glia. 2022 Feb;70(2):239-255. doi: 10.1002/glia.24096. Epub 2021 Sep 24.PMID: 34558120

Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes. Prater KE, Latimer CS, Jayadev S.Glia. 2022 Feb;70(2):239-255. doi: 10.1002/glia.24096. Epub 2021 Sep 24.PMID: 34558120

Genetic counseling for early onset and familial dementia: Patient perspectives on exome sequencing. Rolf B, Blue EE, Bucks S, Dorschner MO, Jayadev S.J Genet Couns. 2021 Jun;30(3):793-802. doi: 10.1002/jgc4.1379. Epub 2021 Jan 3.PMID: 33393146

Molecular estimation of neurodegeneration pseudotime in older brains. Mukherjee S, Heath L, Preuss C, Jayadev S, Garden GA, Greenwood AK, Sieberts SK, De Jager PL, Ertekin-Taner N, Carter GW, Mangravite LM, Logsdon BA.Nat Commun. 2020 Nov 13;11(1):5781. doi: 10.1038/s41467-020-19622-y.PMID: 33188183

Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype. Fung S, Smith CL, Prater KE, Case A, Green K, Osnis L, Winston C, Kinoshita Y, Sopher B, Morrison RS, Garden GA, Jayadev S.J Alzheimers Dis. 2020;77(2):675-688. doi: 10.3233/JAD-200492.PMID: 32741831

Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling
acquisition. Beckman M, Knox K, Koneval Z, Smith C, Jayadev S, Barker-Haliski M.Neurobiol Dis. 2020 Mar;136:104719. doi: 10.1016/j.nbd.2019.104719. Epub 2019 Dec 17.PMID: 31862541

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD,
Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S.Ann Clin Transl Neurol. 2019 Mar 10;6(4):762-777. doi: 10.1002/acn3.755. eCollection 2019 Apr.PMID: 31020001

Enhanced retinal responses in Huntington's disease patients. Pearl JR, Heath LM, Bergey DE, Kelly JP, Smith C, Laurino MY, Weiss A, Price ND, LaSpada A, Bird TD, Jayadev S.J Huntingtons Dis. 2017;6(3):237-247. doi:
10.3233/JHD-170255.PMID: 28968243

Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells. Amos PJ, Fung S, Case A, Kifelew J, Osnis L, Smith CL, Green K, Naydenov A, Aloi M,
Hubbard JJ, Ramakrishnan A, Garden GA, Jayadev S.ASN Neuro. 2017 Jul-Aug;9(4):1759091417716610. doi: 10.1177/1759091417716610.PMID: 28683563

Presenilin 2 influences miR146 level and activity in microglia. Jayadev S, Case A, Alajajian B, Eastman AJ, Möller T, Garden GA.J Neurochem. 2013 Dec;127(5):592-9. doi: 10.1111/jnc.12400. Epub 2013 Sep 30.PMID: 23952003

Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Jayadev S, Nochlin D, Poorkaj P, Steinbart EJ, Mastrianni JA, Montine TJ, Ghetti B, Schellenberg GD, Bird TD, Leverenz JB.Ann Neurol. 2011 Apr;69(4):712-20. doi: 10.1002/ana.22264. Epub 2011 Mar 17.PMID: 21416485

Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2. Jayadev S, Leverenz JB, Steinbart E, Stahl J, Klunk W, Yu CE, Bird TD.Brain. 2010 Apr;133(Pt 4):1143-54. doi: 10.1093/brain/awq033.PMID: 20375137

Conjugal Alzheimer disease: risk in children when both parents have Alzheimer disease. Jayadev S, Steinbart EJ, Chi YY, Kukull WA, Schellenberg GD, Bird TD.Arch Neurol. 2008 Mar;65(3):373-8. doi: 10.1001/archneurol.2007.61.PMID: 18332250