Jayadev Lab
Current Projects
Mechanisms of Disease Driven by Polygenic Risk
Late onset Alzheimer's Disease (LOAD) is genetically heterogeneous. We leverage human variation to study pathway and cell-type specific mechanisms contributing to LOAD and connect genotype to cell-type specific phenotypes.
Immunity and Autosomal Dominant Alzheimer's Disease
Autosomal dominant Alzheimer Disease (ADAD) is driven by pathogenic variants in PSEN1, PSEN2
and APP. We study how immune responses in the brain and periphery of people with ADAD contribute to disease progression. Our goal to identify additional potential therapeutic targets.
Sex Differences in Alzheimer's Disease
Biological sex and APOE genotype impact risk for AD. We investigate how these two factors individually and in concert can affect the function of microglia in human donor tissue with and without AD. This is part of a multi-lab collaboration at UW to understand the role of sex chromosomes in AD.
Molecular Drivers of Glial Biology
Hidden within the diversity of microglial states lie pathways and genes that could be targeted for neurodegenerative disease drug development. We study the regulatory networks driving microglial biology through multiomic analyses of human brain tissues. We study microglial functional phenotypes across normal aging and early-stage disease using multicellular human induced pluripotent stem cell (iPSC) human cell models.
